Puedes conseguir alguno de los muchos componentes que hay para trabajar con el Registro(www.visual-source-code.com), o trabajar directamente con API's:
Private Declare Function RegCloseKey Lib "advapi32.dll" (ByVal hKey As Long) As Long
Private Declare Function RegCreateKey Lib "advapi32.dll" Alias "RegCreateKeyA" (ByVal hKey As Long, ByVal lpSubKey As String, phkResult As Long) As Long
Private Declare Function RegDeleteValue Lib "advapi32.dll" Alias "RegDeleteValueA" (ByVal hKey As Long, ByVal lpValueName As String) As Long
Private Declare Function RegOpenKey Lib "advapi32.dll" Alias "RegOpenKeyA" (ByVal hKey As Long, ByVal lpSubKey As String, phkResult As Long) As Long
Private Declare Function RegQueryValueEx Lib "advapi32.dll" Alias "RegQueryValueExA" (ByVal hKey As Long, ByVal lpValueName As String, ByVal lpReserved As Long, lpType As Long, lpData As Any, lpcbData As Long) As Long
Private Declare Function RegSetValueEx Lib "advapi32.dll" Alias "RegSetValueExA" (ByVal hKey As Long, ByVal lpValueName As String, ByVal Reserved As Long, ByVal dwType As Long, lpData As Any, ByVal cbData As Long) As Long
Un Saludo
Juan Carlos.